Can 'low oxalate' be the next low sodium or sugar? Ingredient startup Entring LLC thinks so

Startup Entring LLC launches Nephure, an oxalate-lowering enzyme

Florida-based startup Entring LLC is launching a nature-identical enzyme of the oxalate decarboxylase type found in blue green algae. Branded as Nephure, it was formulated to support urinary tract health by combating high-oxalate foods.

The concept was conceived in 2009 at a kitchen counter, CEO and co-founder of Entring LLC Helena Cowley told NutraIngredients-USA. “We developed the product because we saw a market need,” she said. “There’s millions of people in the US being recommended a low-oxalate diet, to support kidney and urinary tract health.”

The co-founders recognized that it was “difficult to be on a diet, period,” and wanted to come up with a nutritional ingredient that can regulate the amount of oxalate one consumes (the enzyme in Nephure degrades oxylate). “A low-oxalate diet in particular is difficult [to follow] because oxalate is not on any ingredient label, and there’s no food that’s been manufactured to be low oxalate,” she said.

Whole grains, beans, soy, and nuts can contain oxalate, and so do green vegetables, Cowley said. Typically, the demographic recommended a low-oxalate diet are men, ages 35 to 40, who are prone to kidney stones, one of the effects of having too much oxalate.

Going direct-to-consumer with powders

The enzyme is manufactured in Europe, using a proprietary fermentation process that creates something identical to the compound found in blue algae, purified, then spray dried. Part of Entring LLC’s initial strategy is to sell the powdered oxalate decarboxylase powdered enzyme direct to consumers, to mix in while cooking, baking, and so forth.

During the second quarter of 2017, the company is going through steps for self-affirmed GRAS. "Also, when we prepared the dossier, we did so with a FDA notification in mind," Cowley added. Because Nephure won't be sold as a dietary supplement, Cowley said they are not required to submit a New Dietary Ingredient (NDI) notification. The first powder ingredient is set to launch July 2017.

“The B2B opportunity we recognize has a longer selling cycle, so for our first launch we’re offering it directly to consumers through health stores, strategic partnerships, and our own online store,” Cowley said.

In addition to the population prone to kidney stones, Cowley said the supplement may benefit those who need higher calcium intake.

“Oxalate binds very strongly to calcium in your food [making it] harder for the body to absorb calcium,” Cowley said. “So people who need to absorb more calcium from their foods may benefit from lower oxalate, as it frees up more calcium.”

Grand plan: Working with food manufacturers

As the startup grows, Entring LLC wants to work with food manufacturing companies so that the enzyme can be incorporated during processing to reduce the final oxalate count in the finished product. “We can offer the ingredient to food and beverage manufacturers to make a low-oxalate food,” Cowley said.

She argued that the using the product in food and beverages falls in line with the ‘free-from’ trend, and brands can market low oxalate content or free-from oxalate. “It’s part of the opportunity we’re looking at,” Cowley said.

Related News

Photo: Pixabay

From ingredients out of by-products to Ecopouches, Scelta Mushrooms develops products out of waste-reduction efforts

Photo: iStock/JackF

Study on financial burden of supplements on low-income US households a ‘missed opportunity,’ say experts

Photo: iStock/FikMik

New rat study backs Aquamin’s benefit over traditional calcium for bone health

No longer a ‘startup’: Bulu Box goes from samples to subscriptions

No longer a ‘startup’: Bulu Box goes from samples to subscriptions

Startup VitaCup delivers vitamin-fortified coffee for Keurig system

Brew your vitamins: Startup VitaCup delivers vitamin-fortified coffee for Keurig system

Supplement subscription start-up Vitafive bets on gummies

Gummies Galore: Start-up Vitafive sets up single-serve supplement subscription for just gummies

Hangover? Florida start-up B4 launches supplement to deal with that

Florida start-up B4 targets party-goers with pre-drinking liquid supplement

IStock photo

Supplement to offer structured introduction of potential food allergens into kids' diets

After long voyage, Blue Ocean's shrimp oil omega-3s finally on retail shelves

After long voyage, Blue Ocean's shrimp oil omega-3s finally on retail shelves

Comments (1)

Richard - 05 Aug 2017 | 07:27


Would love to have this product

05-Aug-2017 at 19:27 GMT

Submit a comment

Your comment has been saved

Post a comment

Please note that any information that you supply is protected by our Privacy and Cookie Policy. Access to all documents and request for further information are available to all users at no costs, In order to provide you with this free service, William Reed Business Media SAS does share your information with companies that have content on this site. When you access a document or request further information from this site, your information maybe shared with the owners of that document or information.