“Liposomal technology has been around since the 1960s, but liposomes have traditionally been hard to produce other than in a laboratory enviroment,” liposome expert Bill Heriot told NutraIngredients-USA. Heriot is director of product development for Lippomix, a lipsome technology provider based in Novato, CA.
Liposomes are tiny spheres built up from phospholipids, primarily phosphatidylcholine, the most prevalant constituent of biological membranes, such as cell walls. The spheres, which in some cases range down to nano size, i.e. less than 400 nm in diameter, can be used to encapsulate efficacious molecules like curcumin that don’t absorb well. This approach offers a chemical advantage to the question of bioavailability that competes with mechanical approaches such as finer grinding of ingredients to offer more surface area. But the cost has remainged a hurdle, at least for what Heriot would consider to be true lipsomes.
“There are companies out there making all kinds of claims and I don’t know how they can do it with a straight face,” Heriot said. “In many cases they are using the word lipsome but what they are really offering is emulsions.”
“True lipsomes, if you looked at them under a microscope, would look like a field of ball bearings,” he said.
The big advantage of liposomal technology comes at the surface of the gut, a layer of cells called the epithelium, Heriot said. A true lipsome will latch onto a cell membrane, which has a simliar structure. It can then deliver its payload, even a balky molecule like curcumin, more efficiently into the bloodstream. ‘Naked’ curcumin, as formulators like to refer to the molecule that has had no bioavailability enhancements, is not soluble, and so uptake is poor, and occurs only mechanically so to speak when a curcumin molecule bumps into a receptor on the gut wall.
Heriot said the high cost of the technology has restricted it for the most part to the pharmaceutical realm. Drug companies are well aware of the technology’s benefits, and because of the far higher prices they usually can command for their products, the approach was affordable.
“Traditionally there have been a lot of very successful drugs in liposome form, and the cost of the lipsome was insignificant compared to the cost of the drug,” Heriot said