The study used a combination of seven probiotic strains and an herbal preparation called Bofutsushosan in obese people, and found significant differences in HDL levels, compared with people who received Bofutsushosan alone.
“Changes in gut microbiota of certain phylum or genus such as L. plantarum and Gram negative bacteria showed positive correlation with many body composition parameters and metabolic biomarkers implicating the impact of probiotics on obesity-related energy metabolism,” wrote researchers in Clinical Nutrition.
“Modulation of gut microbiota composition showed close association with both endotoxin and obesity-related parameters.
“From this study, new correlations between parameters affecting endotoxin and gut permeability suggest promising strategies for treatment of obesity by setting a target for gut microbiota modification.”
Gut health and obesity
The study adds to emerging body of science supporting the effects of gut microflora on metabolic factors and obesity.
In 2006, Jeffrey Gordon and his group at Washington University in St. Louis reported in Nature (Vol. 444, pp. 1022-1023, 1027-1031) that microbial populations in the gut are different between obese and lean people, and that when the obese people lost weight their microflora reverted back to that observed in a lean person, suggesting that obesity may have a microbial component.